Principles of general and regulatory proteolysis by AAA plus proteases in Escherichia coli

被引：27

作者：

Schmidt, Ronny ^{[1
]}

Bukau, Bernd ^{[1
]}

Mogk, Axel ^{[1
]}

机构：

[1] Univ Heidelberg, ZMBH, DKFZ ZMBH Alliance, D-69120 Heidelberg, Germany

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 09期

关键词：

AAA protein; Clp/Hsp100; N-end rule; Protein quality control; Proteolysis; N-END RULE; SPECIFICITY-ENHANCING FACTOR; CLPX-RECOGNITION SIGNALS; ADAPTER PROTEIN CLPS; DEGRADATION TAG; SUBSTRATE-SPECIFICITY; DEPENDENT PROTEOLYSIS; STRUCTURAL BASIS; TAGGING SYSTEM; DNA-DAMAGE;

D O I：

10.1016/j.resmic.2009.08.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：629 / 636

页数：8

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