Principles of general and regulatory proteolysis by AAA plus proteases in Escherichia coli

被引：27

作者：

Schmidt, Ronny ^{[1
]}

Bukau, Bernd ^{[1
]}

Mogk, Axel ^{[1
]}

机构：

[1] Univ Heidelberg, ZMBH, DKFZ ZMBH Alliance, D-69120 Heidelberg, Germany

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 09期

关键词：

AAA protein; Clp/Hsp100; N-end rule; Protein quality control; Proteolysis; N-END RULE; SPECIFICITY-ENHANCING FACTOR; CLPX-RECOGNITION SIGNALS; ADAPTER PROTEIN CLPS; DEGRADATION TAG; SUBSTRATE-SPECIFICITY; DEPENDENT PROTEOLYSIS; STRUCTURAL BASIS; TAGGING SYSTEM; DNA-DAMAGE;

D O I：

10.1016/j.resmic.2009.08.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：629 / 636

页数：8

共 50 条

[11] The proteomics of N-terminal methionine cleavage [J].

Frottin, Frederic ;

Martinez, Aude ;

Peynot, Philippe ;

Mitra, Sanghamitra ;

Holz, Richard C. ;

Giglione, Carmela ;

Meinnel, Thierry .

MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (12) :2336-2349

[12] Recognition, targeting, and hydrolysis of the λ O replication protein by the ClpP ClpX protease [J].

Gonciarz-Swiatek, M ;

Wawrzynow, A ;

Um, SJ ;

Learn, BA ;

McMacken, R ;

Kelley, WL ;

Georgopoulos, C ;

Sliekers, O ;

Zylicz, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) :13999-14005

[13] The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system [J].

Gottesman, S ;

Roche, E ;

Zhou, YN ;

Sauer, RT .

GENES & DEVELOPMENT, 1998, 12 (09) :1338-1347

[14] Recognition of misfolded proteins by Lon, a AAA+ protease [J].

Gur, Eyal ;

Sauer, Robert T. .

GENES & DEVELOPMENT, 2008, 22 (16) :2267-2277

[15] Distinct structural elements of the adaptor ClpS are required for regulating degradation by ClpAP [J].

Hou, Jennifer Y. ;

Sauer, Robert T. ;

Baker, Tania A. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (03) :288-294

[16] Synergistic roles of Hs1VU and other ATP-dependent proteases in controlling in vivo turnover of sigma(32) and abnormal proteins in Escherichia coli [J].

Kanemori, M ;

Nishihara, K ;

Yanagi, H ;

Yura, T .

JOURNAL OF BACTERIOLOGY, 1997, 179 (23) :7219-7225

[17] Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA [J].

Keiler, KC ;

Waller, PRH ;

Sauer, RT .

SCIENCE, 1996, 271 (5251) :990-993

[18] The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease [J].

Kirstein, Janine ;

Hoffmann, Anja ;

Lilie, Hauke ;

Schmidt, Ronny ;

Ruebsamen-Waigmann, Helga ;

Broetz-Oesterhelt, Heike ;

Mogk, Axel ;

Turgay, Kuersad .

EMBO MOLECULAR MEDICINE, 2009, 1 (01) :37-49

[19]

KOWIT JD, 1977, J BIOL CHEM, V252, P8350

[20] Role of inorganic polyphosphate in promoting ribosomal, protein degradation by the ion protease in E-coli [J].

Kuroda, A ;

Nomura, K ;

Ohtomo, R ;

Kato, J ;

Ikeda, T ;

Takiguchi, N ;

Ohtake, H ;

Kornberg, A .

SCIENCE, 2001, 293 (5530) :705-708

← 1 2 3 4 5 →