Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development

被引：16

作者：

Cancedda, FD

Dozin, B

Zerega, B

Cermelli, S

Gentili, C

Cancedda, R

机构：

[1] Ctr Biotecnol Avanzate, Ist Nazl Ric Canc, I-16132 Genoa, Italy

[2] CNR, Ctr Studio Neurofisiol Cerebrale, Genoa, Italy

[3] Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2002年 / 239卷 / 1-2期

关键词：

extracellular fatty acid binding protein; lipocalin; hypertrophic cartilage; stress protein;

D O I：

10.1023/A:1020548118241

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular Fatty Acid Binding Protein (Ex-FABP) is a 21 kDa lipocalin, expressed during chicken embryo development in hypertrophic cartilage, in muscle fibres and in blood granulocyte. The protein selectively binds with high affinity fatty acids, preferably long chain unsaturated fatty acids in chondrocyte and myoblast cultures Ex-FABP expression is increased by inflammatory-agents and repressed by anti-inflammatory-agents. In adult cartilage, Ex-FABP is expressed only in pathological conditions such as in dyschondroplastic and osteoarthritic chicken cartilage. We propose that lipocalin Ex-FABP represents a stress protein physiologically expressed in tissues where active remodelling is taking place during development and also present in tissues characterized by a stress response due to pathological conditions.

引用

页码：221 / 225

页数：5