Synthesis of 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol

被引：14

作者：

Kozikowski, AP ^{[1
]}

Qiao, LX ^{[1
]}

Tuckmantel, W ^{[1
]}

Powis, G ^{[1
]}

机构：

[1] ARIZONA CANC CTR, TUCSON, AZ 85724 USA

来源：

TETRAHEDRON | 1997年 / 53卷 / 44期

关键词：

D O I：

10.1016/S0040-4020(97)10003-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol (3 and 18) were synthesized using the regioisomeric mixture of viburnitol 1,2:4,5- and 1,2:5,6- diacetonides as starting material. Selective acidic hydrolysis and subsequent benzylation or deoxygenation afforded 11a,b as important intermediates. Compound 3 and 18 were of interest as putative antimetabolites of phosphatidylinositol-3-phosphate and as inhibitors of cancer cell colony formation. (C) 1997 Elsevier Science Ltd.

引用

页码：14903 / 14914

页数：12

共 33 条

[31] Synthesis of a photoaffinity analogue of phosphatidylinositol 3,4-bisphosphate, an effector in the phosphoinositide 3-kinase signaling pathway [J].