Checkpoint signalling: focusing on 53BP1

被引：46

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1038/ncb1202-e277

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G(2) checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

引用

页码：E277 / E279

页数：3

共 16 条

[1] Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
Anderson, L
Henderson, C
Adachi, Y
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) : 1719 - 1729
[2] A superfamily of conserved domains in DNA damage responsive cell cycle checkpoint proteins
Bork, P
Hofmann, K
Bucher, P
Neuwald, AF
Altschul, SF
Koonin, EV
[J]. FASEB JOURNAL, 1997, 11 (01) : 68 - 76
[3] The second BRCT domain of BRCA-1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
Chai, YL
Cui, JQ
Shao, NS
Reddy, ESP
Rao, VN
[J]. ONCOGENE, 1999, 18 (01) : 263 - 268
[4] Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor
Derbyshire, DJ
Basu, BP
Serpell, LC
Joo, WS
Date, T
Iwabuchi, K
Doherty, AJ
[J]. EMBO JOURNAL, 2002, 21 (14) : 3863 - 3872
[5] 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
DiTullio, RA
Mochan, TA
Venere, M
Bartkova, J
Sehested, M
Bartek, J
Halazonetis, TD
[J]. NATURE CELL BIOLOGY, 2002, 4 (12) : 998 - 1002
[6] DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
Fernandez-Capetillo, O
Chen, HT
Celeste, A
Ward, I
Romanienko, PJ
Morales, JC
Naka, K
Xia, ZF
Camerini-Otero, RD
Motoyama, N
Carpenter, PB
Bonner, WM
Chen, JJ
Nussenzweig, A
[J]. NATURE CELL BIOLOGY, 2002, 4 (12) : 993 - 997
[7] 2 CELLULAR PROTEINS THAT BIND TO WILD-TYPE BUT NOT MUTANT P53
IWABUCHI, K
BARTEL, PL
LI, B
MARRACCINO, R
FIELDS, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) : 6098 - 6102
[8] Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2
Iwabuchi, K
Li, B
Massa, HF
Trask, BJ
Date, T
Fields, S
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 26061 - 26068
[9] Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brcal1 BRCT structure
Joo, WS
Jeffrey, PD
Cantor, SB
Finnin, MS
Livingston, DM
Pavletich, NP
[J]. GENES & DEVELOPMENT, 2002, 16 (05) : 583 - 593
[10] Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor
McGowan, CH
[J]. BIOESSAYS, 2002, 24 (06) : 502 - 511

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