Checkpoint signalling: focusing on 53BP1

被引：46

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1038/ncb1202-e277

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53-binding protein 53BP1 has been implicated in DNA damage responses. Three new reports indicate that 53BP1 is central to both the S and G(2) checkpoints after exposure to ionizing radiation (IR). 53BP1 participates in the organization of nuclear foci and facilitates the phosphorylation of specific substrates by the checkpoint kinase, ataxia-telangiectasia mutated (ATM).

引用

页码：E277 / E279

页数：3

共 16 条

[11] Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways [J].