Concurrent and Discrete Clinicopathological Presentations of Wegener Granulomatosis and Anti-Glomerular Basement Membrane Disease

被引：8

作者：

Clyne, Stephen ^{[2
]}

Frederick, Candice ^{[1
]}

Arndt, Frederick ^{[3
]}

Lewis, Julia ^{[4
]}

Fogo, Agnes B. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA

[2] Kidney Consultants, Pontiac, MI USA

[3] Nephrol Associates Kentuckiana, Louisville, KY USA

[4] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2009年 / 54卷 / 06期

关键词：

Antineutrophil cytoplasmic antibody (ANCA); anti-glomerular basement membrane (anti-GBM) antibody; pulmonary-renal syndrome; dual positivity; Wegener granulomatosis; Goodpasture syndrome; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; PULMONARY RENAL SYNDROME; SEQUENTIAL DEVELOPMENT; CRESCENTIC GLOMERULONEPHRITIS; GOODPASTURES-SYNDROME; CHINESE PATIENTS; GBM ANTIBODIES; ANCA; AUTOANTIBODIES;

D O I：

10.1053/j.ajkd.2009.04.026

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

About 30% of patients with anti-glomerular basement membrane antibody (anti-GBM) disease may also have concomitant antineutrophil cytoplasmic antibody (ANCA) positivity. Both these processes can affect the kidneys and/or lungs. We report a case of a patient with dual positivity for anti-GBM antibodies and ANCAs who underwent both pulmonary and kidney biopsies. There is only 1 previous report in the literature of a patient with dual positivity for anti-GBM antibodies and ANCAs who also underwent both pulmonary and kidney biopsies. Our case is unique in that our patient had dual positivity and also had evidence of unique tissue injury mediated by both antibodies in both the kidneys and lungs. We discuss the significance of dual-antibody positivity based on reported cases. Am J Kidney Dis 54:1116-1120. (C) 2009 by the National Kidney Foundation, Inc.

引用

页码：1116 / 1120

页数：5

共 33 条

[1] A CASE OF GOODPASTURES-SYNDROME ASSOCIATED WITH ANTIMYELOPEROXIDASE ANTIBODIES [J].