A catalytic enantioselective imino-reformatsky reaction

被引：48

作者：

Cozzi, Pier Giorgio ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 15期

关键词：

dimethylzinc; enantioselective; ephedrine; ethyl iodoacetate; Reformatsky reaction;

D O I：

10.1002/adsc.200606178

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The admission of air in the reaction mixture of imine, ethyl iodoacetate and dimethylzinc, in the presence of 20-30 mol % of inexpensive and commercially available N-methylephedrine as the chiral ligand, promoted the Reformatsky reaction, without the need for other metals or catalysts. Excellent yields (up to 92 %) and enantioselectivities (83-94 %) were obtained for the tested substrates. The reaction shows a broad scope, and all the imines are prepared in situ, using Me2Zn as the dehydrating agent.

引用

页码：2075 / 2079

页数：5

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