Heavy metal mutagenicity:: insights from bioinorganic model chemistry

被引：53

作者：

Müller, J ^{[1
]}

Sigel, RKO ^{[1
]}

Lippert, B ^{[1
]}

机构：

[1] Univ Dortmund, Fachbereich Chem, D-44221 Dortmund, Germany

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 79卷 / 1-4期

关键词：

heavy metal mutagenicity; bioinorganic model chemistry;

D O I：

10.1016/S0162-0134(99)00179-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：261 / 265

页数：5

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