HepatomiRNoma: The proposal of a new network of targets for diagnosis, prognosis and therapy in hepatocellular carcinoma

被引：29

作者：

Bronte, Fabrizio ^{[1
]}

Bronte, Giuseppe ^{[2
]}

Fanale, Daniele ^{[2
]}

Caruso, Stefano ^{[2
]}

Bronte, Enrico ^{[2
]}

Bavett, Maria Grazia ^{[1
]}

Fiorentino, Eugenio ^{[2
]}

Rolfo, Christian ^{[3
]}

Bazan, Viviana ^{[2
]}

Di Marco, Vito ^{[1
]}

Russo, Antonio ^{[2
]}

机构：

[1] Univ Palermo, DiBiMIS, Gastroenterol Sect, Palermo, Italy

[2] Univ Palermo, Dept Surg Oncol & Oral Sci, Palermo, Italy

[3] Univ Antwerp Hosp, Dept Oncol, Edegem, Belgium

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 97卷

关键词：

Hepatocellular carcinoma; MicroRNA; Diagnosis; Targeted therapy; Serum; Prognosis; MICRORNA-224; UP-REGULATION; VIRUS X PROTEIN; TUMOR-SUPPRESSOR; DOWN-REGULATION; CANCER-CELLS; ANTI-EGFR; DOXORUBICIN SENSITIVITY; MONOCLONAL-ANTIBODIES; REGULATES EXPRESSION; COLORECTAL-CANCER;

D O I：

10.1016/j.critrevonc.2015.09.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The diagnosis and treatment of hepatocellular carcinoma (HCC) underwent a huge advancement in the last years. Recently, microRNAs (miRNAs) have been also studied to provide a new tool for early diagnosis of high risk patients, for prognostic classification to identify those patients who benefit cancer treatment and for predictive definition to select the right targeted drug. In this review we revised all the available data obtained to explore the role of miRNAs in HCC. This analysis led to identification of miRNAs which could gain a diagnostic, prognostic or predictive role. The results of studies on miRNAs involved in HCC are initial and far from providing scientific evidences to translate into clinical practice. We propose a classification of these miRNAs, that we could name HepatomiRNoma as a whole. Anyway prospective studies have to be designed to clarify the real clinical impact of this new tool. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：312 / 321

页数：10

共 128 条

[1]

Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense? [J].

Amodeo, Valeria ;

Bazan, Viviana ;

Fanale, Daniele ;

Insalaco, Lavinia ;

Caruso, Stefano ;

Cicero, Giuseppe ;

Bronte, Giuseppe ;

Rolfo, Christian ;

Santini, Daniele ;

Russo, Antonio .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (11) :1249-1261

[2]

MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib [J].

Bai, Shoumei ;

Nasser, Mohd W. ;

Wang, Bo ;

Hsu, Shu-Hao ;

Datta, Jharna ;

Kutay, Huban ;

Yadav, Arti ;

Nuovo, Gerard ;

Kumar, Pawan ;

Ghoshal, Kalpana .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (46) :32015-32027

[3]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[4]

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma [J].

Bihrer, Verena ;

Waidmann, Oliver ;

Friedrich-Rust, Mireen ;

Forestier, Nicole ;

Susser, Simone ;

Haupenthal, Joerg ;

Welker, Martin ;

Shi, Ying ;

Peveling-Oberhag, Jan ;

Polta, Andreas ;

von Wagner, Michael ;

Radeke, Heinfried H. ;

Sarrazin, Christoph ;

Trojan, Joerg ;

Zeuzem, Stefan ;

Kronenberger, Bernd ;

Piiper, Albrecht .

PLOS ONE, 2011, 6 (10)

[5]

RNA polymerase III transcribes human microRNAs [J].

Borchert, Glen M. ;

Lanier, William ;

Davidson, Beverly L. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (12) :1097-1101

[6]

Targeted Therapies in Hepatocellular Carcinoma [J].

Bronte, F. ;

Bronte, G. ;

Cusenza, S. ;

Fiorentino, E. ;

Rolfo, C. ;

Cicero, G. ;

Bronte, E. ;

Di Marco, V. ;

Firenze, A. ;

Angarano, G. ;

Fontana, T. ;

Russo, A. .

CURRENT MEDICINAL CHEMISTRY, 2014, 21 (08) :966-974

[7]

Monoclonal antibodies in gastrointestinal cancers [J].

Bronte, Giuseppe ;

Cicero, Giuseppe ;

Cusenza, Stefania ;

Galvano, Antonio ;

Musso, Emmanuela ;

Rizzo, Sergio ;

Sortino, Giovanni ;

Roselli, Mario ;

Bazan, Viviana ;

Fiorentino, Eugenio ;

Russo, Antonio .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (06) :889-900

[8]

Bronte Giuseppe, 2011, Front Biosci (Elite Ed), V3, P879

[9]

Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma [J].

Bronte, Giuseppe ;

Rizzo, Sergio ;

La Paglia, Laura ;

Adamo, Vincenzo ;

Siragusa, Sergio ;

Ficorella, Corrado ;

Santini, Daniele ;

Bazan, Viviana ;

Colucci, Giuseppe ;

Gebbia, Nicola ;

Russo, Antonio .

CANCER TREATMENT REVIEWS, 2010, 36 :S21-S29

[10]

Up-regulation of miR-9 expression predicate advanced clinicopathological features and poor prognosis in patients with hepatocellular carcinoma [J].

Cai, Lizhi ;

Cai, Xi .

DIAGNOSTIC PATHOLOGY, 2014, 9

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