Cortical Firing and Sleep Homeostasis

被引:551
作者
Vyazovskiy, Vladyslav V. [1 ]
Olcese, Umberto [1 ,3 ]
Lazimy, Yaniv M. [1 ]
Faraguna, Ugo [1 ]
Esser, Steve K. [1 ]
Williams, Justin C. [2 ]
Cirelli, Chiara [1 ]
Tononi, Giulio [1 ]
机构
[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53719 USA
[3] Scuola Super Sant Anna, PERCRO Lab, I-56217 Pisa, Italy
关键词
SLOW-WAVE SLEEP; DEPENDENT SYNAPTIC PLASTICITY; LESS-THAN-1 HZ OSCILLATION; DEVELOPING VISUAL-CORTEX; ACTIVITY IN-VIVO; NEOCORTICAL NEURONS; ASSOCIATION CORTEX; CEREBRAL-CORTEX; EEG; RAT;
D O I
10.1016/j.neuron.2009.08.024
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The need to sleep grows with the duration of wakefulness and dissipates with time spent asleep, a process called sleep homeostasis. What are the consequences of staying awake on brain cells, and why is sleep needed? Surprisingly, we do not know whether the firing of cortical neurons is affected by how long an animal has been awake or asleep. Here, we found that after sustained wakefulness cortical neurons fire at higher frequencies in all behavioral states. During early NREM sleep after sustained wakefulness, periods of population activity (ON) are short, frequent, and associated with synchronous firing, while periods of neuronal silence are long and frequent. After sustained sleep, firing rates and synchrony decrease, while the duration of ON periods increases. Changes in firing patterns in NREM sleep correlate with changes in slow-wave activity, a marker of sleep homeostasis. Thus, the systematic increase of firing during wakefulness is counterbalanced by staying asleep.
引用
收藏
页码:865 / 878
页数:14
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