Transitions in infant learning are modulated by dopamine in the amygdala

被引：86

作者：

Barr, Gordon A. ^{[1
,2
]}

Moriceau, Stephanie ^{[3
,4
,5
]}

Shionoya, Kiseko ^{[3
]}

Muzny, Kyle ^{[3
]}

Gao, Puhong ^{[2
]}

Wang, Shaoning ^{[1
,2
]}

Sullivan, Regina M. ^{[3
,4
,5
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA

[2] New York State Psychiat Inst & Hosp, Dept Dev Neurosci, New York, NY 10032 USA

[3] Univ Oklahoma, Dept Zool, Norman, OK 73019 USA

[4] Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY USA

[5] NYU, Langone Med Ctr, New York, NY USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 11期

关键词：

NEURONS; FEAR; ATTRACTION;

D O I：

10.1038/nn.2403

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Behavioral transitions characterize development. Young infant rats paradoxically prefer odors that are paired with shock, but older pups learn aversions. This transition is amygdala and corticosterone dependent. Using microarrays and microdialysis, we found downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone-injected 8-d-old pups and untreated 12-d-old pups learned aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions, whereas dopamine antagonism reinstated preference learning.

引用

页码：1367 / 1369

页数：3

共 15 条

[1] [Anonymous], BRAIN RES
[2] Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition
Bissière, S
Humeau, Y
Lüthi, A
[J]. NATURE NEUROSCIENCE, 2003, 6 (06) : 587 - 592
[3] Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
Breitling, R
Armengaud, P
Amtmann, A
Herzyk, P
[J]. FEBS LETTERS, 2004, 573 (1-3) : 83 - 92
[4] ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia
Galter, D
Buervenich, S
Carmine, A
Anvret, M
Olson, L
[J]. NEUROBIOLOGY OF DISEASE, 2003, 14 (03) : 637 - 647
[5] GLUCOCORTICOID RECEPTOR IMMUNOREACTIVITY IN MONOAMINERGIC NEURONS OF RAT-BRAIN
HARFSTRAND, A
FUXE, K
CINTRA, A
AGNATI, LF
ZINI, I
WIKSTROM, AC
OKRET, S
YU, ZY
GOLDSTEIN, M
STEINBUSCH, H
VERHOFSTAD, A
GUSTAFSSON, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) : 9779 - 9783
[6] Switching on and off fear by distinct neuronal circuits
Herry, Cyril
Ciocchi, Stephane
Senn, Verena
Demmou, Lynda
Mueller, Christian
Luethi, Andreas
[J]. NATURE, 2008, 454 (7204) : 600 - U28
[7] Levine S., 2000, ENCY STRESS, V3, P518
[8] Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior
Maestripieri, D
Lindell, SG
Ayala, A
Gold, PW
Higley, JD
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (01) : 51 - 57
[9] Maternal presence serves as a switch between learning fear and attraction in infancy
Moriceau, Stephanie
Sullivan, Regina M.
[J]. NATURE NEUROSCIENCE, 2006, 9 (08) : 1004 - 1006
[10] Dual circuitry for odor-shock conditioning during infancy: Corticosterone switches between fear and attraction via amygdala
Moriceau, Stephanie
Wilson, Donald A.
Levine, Seymour
Sullivan, Regina M.
[J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (25) : 6737 - 6748

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