A novel synthesis of N-methyl asparagine, arginine, histidine, and tryptophan

被引：35

作者：

Aurelio, L ^{[1
]}

Brownlee, RTC ^{[1
]}

Hughes, AB ^{[1
]}

机构：

[1] La Trobe Univ, Dept Chem, Bundoora, Vic 3086, Australia

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 21期

关键词：

D O I：

10.1021/ol026799w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] N-Methyl amino acid residues in peptides modify several pharmacologically useful parameters, but synthesis of alkylated peptides is hampered by unavailability of N-methylated monomers. The syntheses of four N-methyl amino acids with basic side chains are presented. The side chains of these basic amino acids needed to be specially protected or constructed. This completes the set of 20 common L-amino acid N-methyl derivatives prepared via 5-oxazoildinone intermediates by our group.

引用

页码：3767 / 3769

页数：3

共 19 条

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