Controlled release of dual drugs from emulsion electrospun nanofibrous mats

被引：149

作者：

Su Yan ^{[1
,2
,3
]}

Li Xiaoqiang ^{[1
,2
,3
]}

Liu Shuiping ^{[2
,3
]}

Mo Xiumei ^{[1
,2
,3
]}

Ramakrishna, Seeram ^{[1
,4
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Biomat & Tissue Engn Lab, Shanghai 201620, Peoples R China

[2] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

[3] Donghua Univ, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China

[4] Natl Univ Singapore, Nanosci & Nanotechnol Initiat, Singapore 117576, Singapore

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2009年 / 73卷 / 02期

基金：

美国国家科学基金会;

关键词：

Control release; Emulsion electrospinning; Nanofibers; PLLACL; COMPOSITE NANOFIBERS; ULTRAFINE FIBERS;

D O I：

10.1016/j.colsurfb.2009.06.009

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

The purpose of this work is to develop a novel type of tissue engineering scaffold or drugs delivery carrier with the capability of encapsulation and controlled release drugs. In this study, Rhodamine B and Bovine Serum Albumin (BSA) were successfully incorporated into nanofibers by means of emulsion electrospinning. The morphology of composite nanofibers was studied by Scanning Electron Microscopy (SEM). The composite nanofibrous mats made from emulsion electrospinning were characterized by water contact angle measurement and X-ray diffraction. In vitro dual drugs release behaviors from composite nanofibrous mats were investigated. The results indicated that the incorporated drug and/or proteins in composite fibrous mats made from electrospinning could be control released by adjusting the processes of emulsions preparation. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：376 / 381

页数：6

共 24 条

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