The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

被引:81
作者
Gamba, Gerardo [1 ,2 ]
机构
[1] Univ Nacl Autonoma Mexico, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Inst Invest Biomed, Mol Physiol Unit, Mexico City 04510, DF, Mexico
[2] Inst Nacl Cardiol Ignacio Chavez, Mexico City, DF, Mexico
关键词
distal tubule; ion transport; hypertension; diuretics; PSEUDOHYPOALDOSTERONISM TYPE-II; SODIUM-CHLORIDE COTRANSPORTER; CORTICAL COLLECTING DUCT; AMINO-TERMINAL DOMAIN; K-CL; NACL-COTRANSPORTER; BLOOD-PRESSURE; URINARY-BLADDER; DISTAL TUBULE; CHROMOSOMAL LOCALIZATION;
D O I
10.1152/ajprenal.00159.2009
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Gamba G. The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol 297: F838-F848, 2009. First published May 27, 2009; doi: 10.1152/ajprenal.00159.2009.-The thiazide-sensitive Na+-Cl- cotransporter is the major salt reabsorption pathway in the distal convoluted tubule, which is located just after the macula densa at the beginning of the aldosterone-sensitive nephron. This cotransporter was identified at the molecular level in the early 1990s by the pioneering work of Steven C. Hebert and coworkers, opening the molecular area, not only for the Na+-Cl- cotransporter but also for the family of electroneutral cation-coupled chloride cotransporters that includes the loop diuretic-sensitive Na+-K+-2Cl(-) cotransporter of the thick ascending limb of Henle's loop. This work honoring the memory of Steve Hebert presents a brief review of our current knowledge about salt and water homeostasis generated as a consequence of cloning the cotransporter, with particular emphasis on the molecular biology, physiological properties, human disease due to decreased or increased activity of the cotransporter, and regulation of the cotransporter by a family of serine/threonine kinases known as WNK. Thus one of the legacies of Steve Hebert is a better understanding of salt and water homeostasis.
引用
收藏
页码:F838 / F848
页数:11
相关论文
共 127 条
[61]   Properties of WNK1 and implications for other family members [J].
Lenertz, LY ;
Lee, BH ;
Min, XS ;
Xu, BE ;
Wedin, K ;
Earnest, S ;
Goldsmith, EJ ;
Cobb, MH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26653-26658
[62]   Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human [J].
Loffing, J ;
Kaissling, B .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F628-F643
[63]   Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron [J].
Loffing, J ;
Loffing-Cueni, D ;
Valderrabano, V ;
Kläusli, L ;
Hebert, SC ;
Rossier, BC ;
Hoenderop, JGJ ;
Bindels, RJM ;
Kaissling, B .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 281 (06) :F1021-F1027
[64]   Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21 [J].
Mansfield, TA ;
Simon, DB ;
Farfel, Z ;
Bia, M ;
Tucci, JR ;
Lebel, M ;
Gutkin, M ;
Vialettes, B ;
Christofilis, MA ;
KauppinenMakelin, R ;
Mayan, H ;
Risch, N ;
Lifton, RP .
NATURE GENETICS, 1997, 16 (02) :202-205
[65]   Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3) [J].
Mastroianni, N ;
DeFusco, M ;
Zollo, M ;
Arrigo, G ;
Zuffardi, O ;
Bettinelli, A ;
Ballabio, A ;
Casari, G .
GENOMICS, 1996, 35 (03) :486-493
[66]   Pseudohypoaldosteronism type II: Marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density [J].
Mayan, H ;
Vered, I ;
Mouallem, M ;
Tzadok-Witkon, M ;
Pauzner, R ;
Farfel, Z .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (07) :3248-3254
[67]   NH2-terminal heterogeneity in the KCC3K+-Cl- cotransporter [J].
Mercado, A ;
Vázquez, N ;
Song, LY ;
Cortés, R ;
Enck, AH ;
Welch, R ;
Delpire, E ;
Gamba, G ;
Mount, DB .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 289 (06) :F1246-F1261
[68]   Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4 [J].
Mercado, A ;
Song, LY ;
Vázquez, N ;
Mount, DB ;
Gamba, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :30326-30334
[69]   Characterization of the thiazide-sensitive Na+-Cl- cotransporter:: a new model for ions and diuretics interaction [J].
Monroy, A ;
Plata, C ;
Hebert, SC ;
Gamba, G .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (01) :F161-F169
[70]   A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity [J].
Moreno, E ;
Tovar-Palacio, C ;
de los Heros, P ;
Guzmán, B ;
Bobadilla, NA ;
Vázquez, N ;
Riccardi, D ;
Poch, E ;
Gamba, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) :16553-16560