The brucine N-oxide-promoted asymmetric Pauson-Khand reaction

被引：45

作者：

Kerr, WJ ^{[1
]}

Lindsay, DM

Rankin, EM

Scott, JS

Watson, SP

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

amine N-oxides; asymmetric synthesis; cobalt and compounds; cyclopentenones; Pauson-Khand reactions;

D O I：

10.1016/S0040-4039(00)00357-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The brucine N-oxide-mediated asymmetric Pauson-Khand reaction has been further investigated. It was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes. The studies also revealed that when acetone or 1,2-dimethoxyethane is used as the reaction solvent, enhanced levels of enantioselectivity, up to an enantiomeric ratio of 11:89, are achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3229 / 3233

页数：5

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