HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata

被引：36

作者：

Kim, HJ ^{[1
]}

Yu, YG ^{[1
]}

Park, H ^{[1
]}

Lee, YS ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 11期

关键词：

D O I：

10.1055/s-2002-35665

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

By means of HIV gp41 binding affinity directed chromatographic fractionation, three phenylethanoid glycosides; calceolarioside A (1), calceolarioside B (2) and acteoside (3), along with four hydroxycoumarins; esculin (4), fraxin (5), fraxetin (6) and esculetin (7), and one lignan, (-)-olivil (8) were isolated from the n-butyl alcohol fraction of Fraxinus sieboldiana var. angustata. Among the isolated compounds, calceolarioside B (2) and esculetin (7) showed moderate binding affinity on HIV gp41 with IC50 values of 0.1 mg/ml and 0.5 mg/ml, respectively. Calceolarioside A (1), calceolarioside B (2), acteoside (3), and (-)-olivil (8) were isolated for the first time from this plant.

引用

页码：1034 / 1036

页数：3