New insights into the regulation of TLR signaling

被引：209

作者：

Miggin, Sinead M. ^{[1
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2006年 / 80卷 / 02期

关键词：

inflammation; regulatory molecules;

D O I：

10.1189/jlb.1105672

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level. J. Leukoc. Biol. 80: 220-226; 2006.

引用

页码：220 / 226

页数：7

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