A ruthenium-catalyzed one-pot method for α-alkylation of ketones with aldehydes

被引：37

作者：

Cho, Chan Sik

Shim, Sang Chul

机构：

[1] Kyungpook Natl Univ, Ind Technol Res Inst, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Coll Engn, Dept Appl Chem, Taegu 702701, South Korea

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2006年 / 691卷 / 20期

关键词：

aldehydes; aldol reaction; alpha-alkylation; ketones; reduction; ruthenium catalyst;

D O I：

10.1016/j.jorganchem.2006.07.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ketones react with an array of aldehydes in dioxane at 80 degrees C in the presence of a catalytic amount of RuCl2(PPh3)(3) along with KOH to give the corresponding alpha-alkylated ketones in moderate to good yields. A reaction pathway involving base-catalyzed cross-aldol reaction between ketones and aldehydes to form alpha,beta-unsaturated ketones and regioselective reduction of carbon-carbon double bond of alpha,beta-unsaturated ketones is proposed for this catalytic process. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：4329 / 4332

页数：4

共 28 条

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