Increased Penicillin Nonsusceptibility of Nonvaccine-Serotype Invasive Pneumococci Other than Serotypes 19A and 6A in Post-7-Valent Conjugate Vaccine Era

被引：92

作者：

Gertz, Robert E. ^{[1
]}

Li, Zhongya ^{[1
]}

Pimenta, Fabiana C. ^{[1
]}

Jackson, Delois ^{[1
]}

Juni, Billie A. ^{[2
]}

Lynfield, Ruth ^{[2
]}

Jorgensen, James H. ^{[3
]}

Carvalho, Maria da Gloria

Beall, Bernard W. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[3] Minnesota Dept Hlth, Minneapolis, MN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 05期

关键词：

STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; DISEASE; CHILDREN; ADULTS; CLONE;

D O I：

10.1086/650496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to population-based invasive pneumococcal surveillance in the United States during 2007, 898 (26%) of 3,511 isolates were penicillin nonsusceptible. Non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes other than 19A accounted for 40% of these penicillin-nonsusceptible isolates; of these, serotypes 15A (11%), 23A (8%), 35B (8%), and 6C (5%) were most common (cumulatively 32% of penicillin-nonsusceptible isolates). Each except 6C represented a single serotype and clonal complex combination that predated the introduction of PCV7. We evaluated the genetic characteristics and nonsusceptibility to penicillin of non-PCV7 serotypes, and we found increased proportions of specific penicillin-nonsusceptible clones in serotypes 15A, 23A, 35B, and 6C, which potentially indicates a basic change of population structure within these individual serotypes.

引用

页码：770 / 775

页数：6

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