New approach to the study of particle-surface adhesion using atomic force microscopy

被引:32
作者
Willing, GA
Ibrahim, TH
Etzler, FM
Neuman, RD [1 ]
机构
[1] Auburn Univ, Dept Chem Engn, Auburn, AL 36849 USA
[2] Boehringer Ingelheim Pharmaceut Inc, Ctr Res & Dev, Ridgefield, CT 06877 USA
关键词
adhesion; AFM; colloidal probe; particle-surface adhesion; spatial variation of adhesion; adhesion force; lactose; gelatin capsule;
D O I
10.1006/jcis.2000.6801
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The colloidal probe technique is commonly employed to determine the adhesion force between a particle and a solid surface. Characterization of the adhesion of a particle across a surface can be as important, if not more so, as the determination of an average value for the adhesion. Unfortunately, the measurement of the variation in adhesion can be difficult at best. A new approach for studying particle-surface adhesion based on the force-volume technique is presented. Upon combining the force-volume technique with a colloidal probe, not only is it possible to determine the average adhesion force, but an image of the spatial variation of the adhesion can also be obtained. This method is envisioned to have great potential for examining and analyzing the adhesion behavior in complex natural and technological systems. (C) 2000 Academic Press.
引用
收藏
页码:185 / 188
页数:4
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