Responsive micelles and vesicles based on polypeptide diblock copolymers

被引：15

作者：

Checot, F. ^{[1
]}

Rodriguez-Hernandez, J. ^{[1
]}

Gnanou, Y. ^{[1
]}

Lecommandoux, S. ^{[1
]}

机构：

[1] Univ Bordeaux 1, CNRS, UMR5629, LCPO,ENSCPB, F-33607 Pessac, France

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2006年 / 17卷 / 9-10期

关键词：

block copolymers; self-assembly; vesicles; polypeptide; responsive;

D O I：

10.1002/pat.821

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with a control size and shape. Results focusing on vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical application will be detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems that are able to form vesicles with narrow size distributions at basic and acidic pH going through an intermediate state of single polymer chains are presented. These nanoparticles are particularly interesting for encapsulation and delivery purposes at a controlled pH. Finally, surface self-assembly of micelles and vesicles will be shown as models for biological surfaces such as mucosal surfaces. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：782 / 785

页数：4

共 12 条

[1] Self-assembled nanostructures from peptide-synthetic hybrid block copolymers: Complex, stimuli-responsive rod-coil architectures [J].

Babin, J ;

Rodriguez-Hernandez, J ;

Lecommandoux, S ;

Klok, HA ;

Achard, MF .

FARADAY DISCUSSIONS, 2005, 128 :179-192

[2] Stimuli-responsive polypeptide vesicles by conformation-specific assembly [J].

Bellomo, EG ;

Wyrsta, MD ;

Pakstis, L ;

Pochan, DJ ;

Deming, TJ .

NATURE MATERIALS, 2004, 3 (04) :244-248

[3] Structure of polypeptide-based diblock copolymers in solution:: Stimuli-responsive vesicles and micelles [J].

Chécot, F ;

Brûlet, A ;

Oberdisse, J ;

Gnanou, Y ;

Mondain-Monval, O ;

Lecommandoux, S .

LANGMUIR, 2005, 21 (10) :4308-4315

[4]

Chécot F, 2002, ANGEW CHEM INT EDIT, V41, P1339, DOI 10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO

[5]

2-N

[6]

COTTON JP, 1991, NEUTRON XRAY LIGHT S, P1

[7] Synthesis and characterization of glycopolymer-polypeptide triblock copolymers [J].

Dong, CM ;

Sun, XL ;

Faucher, KM ;

Apkarian, RP ;

Chaikof, EL .

BIOMACROMOLECULES, 2004, 5 (01) :224-231

[8]

GUANGZHUO R, 2003, BIOMACROMOLECULES, V4, P1800

[9] Self-assembly of peptide-based diblock oligomers [J].

Klok, HA ;

Langenwalter, JF ;

Lecommandoux, S .

MACROMOLECULES, 2000, 33 (21) :7819-7826

[10] The formation of polymer vesicles or "peptosomes" by polybutadiene-block-poly(L-glutamate)s in dilute aqueous solution [J].

Kukula, H ;

Schlaad, H ;

Antonietti, M ;

Förster, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) :1658-1663

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