Towards a universal group B Streptococcus vaccine using multistrain genome analysis

被引：18

作者：

Tettelin, Herve

Medini, Duccio

Donati, Claudino

Masignani, Vega

机构：

[1] Inst Genom Res, Dept Microbial Genom, TIGR, Rockville, MD 20850 USA

[2] Novartis Vaccines, IRIS, I-53100 Siena, Italy

来源：

EXPERT REVIEW OF VACCINES | 2006年 / 5卷 / 05期

关键词：

genome; genomics; pan-genome; reverse; vaccinology; species diversity; vaccine;

D O I：

10.1586/14760584.5.5.687

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genomics has revolutionized the way in which novel vaccine candidates are identified for the development of efficacious vaccines. Reverse vaccinology, whereby all candidates of interest are identified by analysis of a pathogen's genome, enables characterization of many candidates simultaneously. It accelerates the initial steps of vaccine development and greatly increases the chances of obtaining reliable candidates or cocktails thereof. The availability of one or two genome sequences for any given pathogen provides access to strain-specific vaccine candidates but often fails to identify candidates that would confer general protection. The analysis of multiple genomes of group B Streptococcus revealed tremendous diversity and identified candidates that are not shared by all the strains sequenced, but provide general protection when combined.

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收藏

页码：687 / 694

页数：8

相关论文

共 34 条

[1] Genomic diversity and evolution within the species Streptococcus agalactiae [J].

Brochet, Mathieu ;

Couve, Elisabeth ;

Zouine, Mohamed ;

Vallaeys, Tatiana ;

Rusniok, Christophe ;

Lamy, Marie-Cecile ;

Buchrieser, Carmen ;

Trieu-Cuot, Patrick ;

Kunst, Frank ;

Poyart, Claire ;

Glaser, Philippe .

MICROBES AND INFECTION, 2006, 8 (05) :1227-1243

[2] NadA diversity and carriage in Neisseria meningitidis [J].

Comanducci, M ;

Bambini, S ;

Caugant, DA ;

Mora, M ;

Brunelli, B ;

Capecchi, B ;

Ciucchi, L ;

Rappuoli, R ;

Pizza, M .

INFECTION AND IMMUNITY, 2004, 72 (07) :4217-4223

[3] Multilocus sequence typing of serotype III group B streptococcus and correlation with pathogenic potential [J].

Davies, HD ;

Jones, N ;

Whittam, TS ;

Elsayed, S ;

Bisharat, N ;

Baker, CJ .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (06) :1097-1102

[4]

DEGROOT SA, 2004, EXPERT REV VAC, V3, P59

[5] The value of complete microbial genome Sequencing (you get what you pay for) [J].

Fraser, CM ;

Eisen, JA ;

Nelson, KE ;

Paulsen, IT ;

Salzberg, SL .

JOURNAL OF BACTERIOLOGY, 2002, 184 (23) :6403-6405

[6] Can laboratory reference strains mirror 'real-world' pathogenesis? [J].

Fux, CA ;

Shirtliff, M ;

Stoodley, P ;

Costerton, JW .

TRENDS IN MICROBIOLOGY, 2005, 13 (02) :58-63

[7] Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease [J].

Glaser, P ;

Rusniok, C ;

Buchrieser, C ;

Chevalier, F ;

Frangeul, L ;

Msadek, T ;

Zouine, M ;

Couvé, E ;

Lalioui, L ;

Poyart, C ;

Trieu-Cuot, P ;

Kunst, F .

MOLECULAR MICROBIOLOGY, 2002, 45 (06) :1499-1513

[8] Serotype distribution of invasive group B streptococcal isolates in Maryland: Implications for vaccine formulation [J].

Harrison, LH ;

Elliott, JA ;

Dwyer, DM ;

Libonati, JP ;

Ferrieri, P ;

Billmann, L ;

Schuchat, A .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (04) :998-1002

[9] Multilocus sequence typing system for group B streptococcus [J].

Jones, N ;

Bohnsack, JF ;

Takahashi, S ;

Oliver, KA ;

Chan, MS ;

Kunst, F ;

Glaser, P ;

Rusniok, C ;

Crook, DWM ;

Harding, RM ;

Bisharat, N ;

Spratt, BG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (06) :2530-2536

[10] Genome evolution in bacteria: order beneath chaos [J].

Lawrence, JG ;

Hendrickson, H .

CURRENT OPINION IN MICROBIOLOGY, 2005, 8 (05) :572-578

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