Towards a universal group B Streptococcus vaccine using multistrain genome analysis

被引：18

作者：

Tettelin, Herve

Medini, Duccio

Donati, Claudino

Masignani, Vega

机构：

[1] Inst Genom Res, Dept Microbial Genom, TIGR, Rockville, MD 20850 USA

[2] Novartis Vaccines, IRIS, I-53100 Siena, Italy

来源：

EXPERT REVIEW OF VACCINES | 2006年 / 5卷 / 05期

关键词：

genome; genomics; pan-genome; reverse; vaccinology; species diversity; vaccine;

D O I：

10.1586/14760584.5.5.687

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genomics has revolutionized the way in which novel vaccine candidates are identified for the development of efficacious vaccines. Reverse vaccinology, whereby all candidates of interest are identified by analysis of a pathogen's genome, enables characterization of many candidates simultaneously. It accelerates the initial steps of vaccine development and greatly increases the chances of obtaining reliable candidates or cocktails thereof. The availability of one or two genome sequences for any given pathogen provides access to strain-specific vaccine candidates but often fails to identify candidates that would confer general protection. The analysis of multiple genomes of group B Streptococcus revealed tremendous diversity and identified candidates that are not shared by all the strains sequenced, but provide general protection when combined.

引用

页码：687 / 694

页数：8

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