Enterobacteriaceae from community acquired urinary tract infections: AFORCOPIBIO 1995

A prospective multicenter study was performed during two months (May and June 1995) by ten private clinical laboratories which collected 700 Enterobacteriaceae in 849 patients with community acquired urinary tract infection. Isolated E. coli rate (70.2%) was the same as in 1990. Susceptibility to amoxicillin, amoxicillin-clavulanic acid, and cotrimoxazole had decreased. Susceptibility to fluoroquinolons, third generation cephalosporins, and fosfomycin remained stable. Among 178 E. coli cases, decreased susceptibility to aminopenicillin was mainly due to penicillinase (TEM-1: 86.5%; TEM-2: 1.7%, OXA: 1.7% and TRI: 5.7%) and in the other cases to the hyperproduction of cephalosporinase (2.8%), combined cephalosporinase + penicillinase (0.6%). P. mirabilis resistant strains expressed penicillinase TEM-1 in five cases and TEM-2 in three cases. Among nn 53 other Enterobacteriaceae, 4 out of 18 K. Pnenmoniae produced an extended spectrum beta-lactamase (SHV-2 enzyme) and 7 out of 25 Enterobacteriaceae overproduced their chromosomal cephalosporinase.