Women's Angiographic Vitamin and Estrogen trial: Design and methods

被引：18

作者：

Hsia, J

Alderman, EL

Verter, JI

Rogers, WJ

Thompson, P

Howard, BV

Cobb, FR

Ouyang, P

Tardif, JC

Higginson, L

Bittner, V

Barofsky, I

Steffes, M

Gordon, DJ

Proschan, M

Younes, N

Waters, D

机构：

[1] George Washington Univ, Dept Med, Washington, DC USA

[2] Stanford Univ, Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

[3] George Washington Univ, Dept Stat, Washington, DC 20052 USA

[4] Univ Alabama, Dept Cariol, Birmingham, AL USA

[5] Hartford Hosp, Div Cardiol, Hartford, CT 06115 USA

[6] Medstar Res Inst, Washington, DC USA

[7] Duke Univ, Duke Ctr Living, Durham, NC USA

[8] Johns Hopkins Bayview Med Ctr, Div Cardiol, Baltimore, MD USA

[9] Inst Cardiol Montreal, Montreal, PQ, Canada

[10] Univ Ottawa, Inst Heart, Ottawa, ON, Canada

[11] Johns Hopkins Univ, Med Ctr, Div Digest Dis, Baltimore, MD 21218 USA

[12] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[13] NHLBI, NIH, Bethesda, MD 20892 USA

[14] San Francisco Gen Hosp, Div Cardiol, San Francisco, CA 94110 USA

来源：

CONTROLLED CLINICAL TRIALS | 2002年 / 23卷 / 06期

关键词：

estrogen; antioxidants; coronary heart disease; coronary angiography;

D O I：

10.1016/S0197-2456(02)00237-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Women's Angiographic Vitamin and Estrogen trial was a randomized, double-blind, placebo-controlled study designed to test the efficacy of estrogen replacement and antioxidant vitamins for preventing angiographic progression of coronary artery disease. Postmenopausal women with one or more angiographically documented coronary stenoses of 15-75% at baseline were assigned in a 2X2 factorial randomization to active hormone replacement therapy (conjugated estrogens for women who had had a hysterectomy or conjugated estrogens with medroxyprogesterone for women with intact uteri) or placebo and to active vitamins E and C or their placebos. Seven clinical centers, five in the United States and two in Canada, randomized 423 women between July 1997 and July 1999. Quantitative coronary angiography was performed at baseline and repeated after projected mean follow-up of 3 years. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：708 / 727

页数：20

共 83 条

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