The influence of microenvironment on tumor immunotherapy

被引：109

作者：

Zhang, Jieying ^{[1
,2
]}

Shi, Zhaopeng ^{[1
]}

Xu, Xiang ^{[1
]}

Yu, Zuoren ^{[2
]}

Mi, Jun ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Chinese Minist Educ,Key Lab Cell Differentiat & A, Shanghai, Peoples R China

[2] Tongji Univ, East Hosp, Sch Med, Res Ctr Translat Med, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Hongqiao Int Inst Med, Shanghai, Peoples R China

来源：

FEBS JOURNAL | 2019年 / 286卷 / 21期

基金：

美国国家科学基金会;

关键词：

cancer-associated fibroblasts; tumor immunotherapy; tumor microenvironment; ARYL-HYDROCARBON RECEPTOR; CANCER-ASSOCIATED FIBROBLASTS; MESENCHYMAL STEM-CELLS; REGULATORY T-CELLS; BREAST-CANCER; INDOLEAMINE 2,3-DIOXYGENASE; SUCCINATE-DEHYDROGENASE; IMMUNE SUPPRESSION; GLUTAMINE UPTAKE; ITACONIC ACID;

D O I：

10.1111/febs.15028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor immunotherapy has achieved remarkable efficacy, with immune-checkpoint inhibitors as especially promising candidates for cancer therapy. However, some issues caused by immunotherapy have raised attention, such as limited efficacy for some patients, narrow antineoplastic spectrum, and adverse reactions, suggesting that using regulators of tumor immune response may prove to be more complicated than anticipated. Current evidence indicates that different factors collectively constituting the unique tumor microenvironment promote immune tolerance, and these include the expression of co-inhibitory molecules, the secretion of lactate, and competition for nutrients between tumor cells and immune cells. Furthermore, cancer-associated fibroblasts, the main cellular components of solid tumors, promote immunosuppression through inhibition of T cell function and extracellular matrix remodeling. Here, we summarize the research advances in tumor immunotherapy and the latest insights into the influence of microenvironment on tumor immunotherapy.

引用

页码：4160 / 4175

页数：16

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