Resonance Raman spectroscopy in malaria research

被引：39

作者：

Wood, Bayden R. ^{[1
]}

McNaughton, Don

机构：

[1] Monash Univ, Ctr Biospect, Clayton, Vic 3800, Australia

[2] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

来源：

EXPERT REVIEW OF PROTEOMICS | 2006年 / 3卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

antimalarial; beta-hematin; hemozoin; malaria; resonance Raman spectroscopy;

D O I：

10.1586/14789450.3.5.525

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the field of Raman spectroscopy has witnessed a surge in technological development, with the incorporation of ultrasensitive, charge-coupled devices, improved laser sources and precision Rayleigh-filter systems. This has led to the development of sensitive confocal micro-Raman spectrometers and imaging spectrometers that are capable of obtaining high spatial-resolution spectra and images of subcellular components within single living cells. This review reports on the application of resonance micro-Raman spectroscopy to the study of malaria pigment (hemozoin), a by-product of hemoglobin catabolization by the malaria parasite, which is an important target site for antimalarial drugs. The review aims to briefly describe recent studies on the application of this technology, elucidate molecular and electronic properties of the malaria pigment and its synthetic analog P-hematin, provide insight into the mechanism of hemozoin formation within the food vacuole of the parasite, and comment on developing strategies for using this technology in drug-screening protocols.

引用

页码：525 / 544

页数：20

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