Generation and reactivity of α-amino-substituted arylmethyllithium organometallics

被引：18

作者：

Azzena, U

Pilo, L

Piras, E

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Univ Sassari, Fac Farm, I-07100 Sassari, Italy

来源：

TETRAHEDRON | 2000年 / 56卷 / 23期

关键词：

amines; carbanions; ethers; lithium and compounds; reduction;

D O I：

10.1016/S0040-4020(00)00303-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductive cleavage of open chain and cyclic alpha-N,N-dialkylamino-substituted benzyl alkyl ethers 1a-f with a dispersion of Li metal and a catalytic amount of naphthalene in THF, allowed easy access to a wide array of alpha-N,N-dialkylamino-substituted benzyllithium derivatives. Reaction of these organometallics with various electrophiles afforded the expected products in satisfactory yields. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：3775 / 3780

页数：6

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