Determination of antimicrobial residues and metabolites in the aquatic environment by liquid chromatography tandem mass spectrometry

被引：102

作者：

Diaz-Cruz, M. Silvia ^{[1
]}

Barcelo, Damia ^{[1
]}

机构：

[1] CSIC, IIQAB, Dept Environm Biochem, ES-08034 Barcelona, Spain

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2006年 / 386卷 / 04期

关键词：

antimicrobials; pharmaceuticals; solid-phase extraction; liquid chromatography tandem mass spectrometry; water analysis;

D O I：

10.1007/s00216-006-0444-z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobials are used in large quantities in human and veterinary medicine. Their environmental occurrence is of particular concern due to the potential spread and maintenance of bacterial resistance. After intake by the organisms, the unchanged drug and its metabolized forms are excreted and enter wastewater treatment plants where they are mostly incompletely eliminated, and are therefore eventually released into the aquatic environment. The reliable detection of several antimicrobials in different environmental aqueous compartments is the result of great improvements achieved in analytical chemistry. This article provides an overview of the more outstanding analytical methods based on liquid chromatography tandem mass spectrometry, developed and applied to determine antimicrobial residues and metabolites present in surface, waste, and ground waters.

引用

页码：973 / 985

页数：13

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