The influence of natural products upon drug discovery

被引:859
作者
Newman, DJ
Cragg, GM
Snader, KM
机构
[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Rockville, MD 20852 USA
[2] NCI, Pharmaceut Resources Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Rockville, MD 20852 USA
关键词
D O I
10.1039/a902202c
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:215 / 234
页数:20
相关论文
共 208 条
[81]   BETA-LACTAMASE HYDROLYSIS OF CEPHALOSPORIN 3'-QUINOLONE ESTERS, CARBAMATES, AND TERTIARY-AMINES [J].
GEORGOPAPADAKOU, NH ;
MCCAFFREY, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) :959-962
[82]   Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties [J].
Gerth, K ;
Bedorf, N ;
Hofle, G ;
Irschik, H ;
Reichenbach, H .
JOURNAL OF ANTIBIOTICS, 1996, 49 (06) :560-563
[83]   HPMA copolymer platinates as novel antitumour agents:: In vitro properties, pharmacokinetics and antitumour activity in vivo [J].
Gianasi, E ;
Wasil, M ;
Evagorou, EG ;
Keddle, A ;
Wilson, G ;
Duncan, R .
EUROPEAN JOURNAL OF CANCER, 1999, 35 (06) :994-1002
[84]  
GOLDSTEIN A, 1984, OPIOIDS PAST PRESENT, P127
[85]  
GRABLEY S, 1999, ADV BIOCHEM ENG BIOT, V64, P104
[86]  
Gray N, 1999, CURR MED CHEM, V6, P859
[87]   Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors [J].
Gray, NS ;
Wodicka, L ;
Thunnissen, AMWH ;
Norman, TC ;
Kwon, SJ ;
Espinoza, FH ;
Morgan, DO ;
Barnes, G ;
LeClerc, S ;
Meijer, L ;
Kim, SH ;
Lockhart, DJ ;
Schultz, PG .
SCIENCE, 1998, 281 (5376) :533-538
[88]  
Grifo F, 1997, ORIGINS PRESCRIPTION, P131
[89]  
GUSSIO R, 1999, P AACR NCI EORTC M
[90]   The coral-derived natural products eleutherobin and sarcodictyins A and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site [J].
Hamel, E ;
Sackett, DL ;
Vourloumis, D ;
Nicolaou, KC .
BIOCHEMISTRY, 1999, 38 (17) :5490-5498