Magnetic resonance imaging in cancer research

被引：25

作者：

Ross, BD

Chenevert, TL

Rehemtulla, A

机构：

[1] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2002年 / 38卷 / 16期

关键词：

MRI; yeast cytosine deaminase; bioluminescence imaging (BLI); molecular imaging; glioma; cancer gene therapy;

D O I：

10.1016/S0959-8049(02)00387-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-invasive assessment of antineoplastic response and correlation of the location, magnitude and duration of transgene expression in vivo would be particularly useful for evaluating cancer gene therapy protocols. This review presents selected examples of how magnetic resonance (MR) has been used to assess therapeutic efficacy by non-invasive quantitation of cell kill, to detect a therapeutic response prior to a change in tumour volume and to detect spatial heterogeneity of the tumour response and quantitate transgene expression. In addition, applications of the use of bioluminescence imaging (BLI) for the evaluation of treatment efficacy and in vivo transgene expression are also presented. These examples provide an overview of areas in which imaging of animal tumour models can contribute towards improving the evaluation of experimental therapeutic agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2147 / 2156

页数：10

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