Magnetic resonance imaging in cancer research

被引：25

作者：

Ross, BD

Chenevert, TL

Rehemtulla, A

机构：

[1] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2002年 / 38卷 / 16期

关键词：

MRI; yeast cytosine deaminase; bioluminescence imaging (BLI); molecular imaging; glioma; cancer gene therapy;

D O I：

10.1016/S0959-8049(02)00387-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-invasive assessment of antineoplastic response and correlation of the location, magnitude and duration of transgene expression in vivo would be particularly useful for evaluating cancer gene therapy protocols. This review presents selected examples of how magnetic resonance (MR) has been used to assess therapeutic efficacy by non-invasive quantitation of cell kill, to detect a therapeutic response prior to a change in tumour volume and to detect spatial heterogeneity of the tumour response and quantitate transgene expression. In addition, applications of the use of bioluminescence imaging (BLI) for the evaluation of treatment efficacy and in vivo transgene expression are also presented. These examples provide an overview of areas in which imaging of animal tumour models can contribute towards improving the evaluation of experimental therapeutic agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2147 / 2156

页数：10

共 50 条

[31] High resolution X-ray computed tomography: An emerging tool for small animal cancer research [J].

Paulus, MJ ;

Gleason, SS ;

Kennel, SJ ;

Hunsicker, PR ;

Johnson, DK .

NEOPLASIA, 2000, 2 (1-2) :62-70

[32] Coregulation of glucose uptake and vascular endothelial growth factor (VEGF) in two small-cell lung cancer (SCLC) sublines in vivo and in vitro [J].

Pedersen, MWB ;

Holm, S ;

Lund, EL ;

Hojgaard, L ;

Kristjansen, PEG .

NEOPLASIA, 2001, 3 (01) :80-87

[33] Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: The metabolic Boyden Chamber [J].

Pilatus, U ;

Ackerstaff, E ;

Artemov, D ;

Mori, N ;

Gillies, RJ ;

Bhujwalla, ZM .

NEOPLASIA, 2000, 2 (03) :273-279

[34] Imaging TCR-dependent NFAT-mediated T-cell activation with positron emission tomography in vivo [J].

Ponomarev, V ;

Doubrovin, M ;

Lyddane, C ;

Beresten, T ;

Balatoni, J ;

Bornman, W ;

Finn, R ;

Akhurst, T ;

Larson, S ;

Blasberg, R ;

Sadelain, M ;

Tjuvajev, JG .

NEOPLASIA, 2001, 3 (06) :480-488

[35] Fluorescence spectroscopy of neoplastic and non-neoplastic tissues [J].

Ramanujam, N .

NEOPLASIA, 2000, 2 (1-2) :89-117

[36] Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging [J].

Rehemtulla, A ;

Stegman, LD ;

Cardozo, SJ ;

Gupta, S ;

Hall, DE ;

Contag, CH ;

Ross, BD .

NEOPLASIA, 2000, 2 (06) :491-495

[37] Molecular Imaging of Gene Expression and Efficacy following Adenoviral-Mediated Brain Tumor Gene Therapy [J].

Rehemtulla, Alnawaz ;

Hall, Daniel E. ;

Stegman, Lauren D. ;

Prasad, Uttara ;

Chen, Grace ;

Bhojani, Mahaveer Swaroop ;

Chenevert, Thomas L. ;

Ross, Brian D. .

MOLECULAR IMAGING, 2002, 1 (01) :43-62

[38] Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: An MRI study [J].

Ross, BD ;

Zhao, YJ ;

Neal, ER ;

Stegman, LD ;

Ercolani, M ;

Ben-Yoseph, O ;

Chenevert, TL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :7012-7017

[39]

ROSS BD, 1997, ADV NEUROCH, V8, P145

[40]

Ross Brian D, 1994, Q Magn Reson Biol Med, V1, P89

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