Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

被引：103

作者：

Jourdain, Alexis ^{[1
]}

Martinou, Jean-Claude ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 10期

关键词：

Apoptosis; Mitochondria; Bax; Bcl-2; Drp-1; Mitochondrial fusion; Mitochondrial fission; CYTOCHROME-C RELEASE; BCL-2 PROTEIN FAMILY; DYNAMIN-RELATED GTPASE; PROGRAMMED CELL-DEATH; MARIE-TOOTH-DISEASE; MAMMALIAN-CELLS; CONFORMATIONAL-CHANGE; PROTEOLYTIC CLEAVAGE; FISSION MACHINERY; TRIGGER APOPTOSIS;

D O I：

10.1016/j.biocel.2009.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1884 / 1889

页数：6

共 97 条

[11] Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization [J].

Cassidy-Stone, Ann ;

Chipuk, Jerry E. ;

Ingerman', Elena ;

Song, Cheng ;

Yoo, Choong ;

Kuwana, Tomomi ;

Kurth, Mark J. ;

Shaw, Jared T. ;

Hinshaw, Jenny E. ;

Green, Douglas R. ;

Nunnari, Jodi .

DEVELOPMENTAL CELL, 2008, 14 (02) :193-204

[12] Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria [J].

Cereghetti, G. M. ;

Stangherlin, A. ;

de Brito, O. Martins ;

Chang, C. R. ;

Blackstone, C. ;

Bernardi, P. ;

Scorrano, L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) :15803-15808

[13] Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology [J].

Chang, Chuang-Rung ;

Blackstone, Craig .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (30) :21583-21587

[14] OPA1 requires mitofusin 1 to promote mitochondrial fusion [J].

Cipolat, S ;

de Brito, OM ;

Dal Zilio, B ;

Scorrano, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15927-15932

[15] Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling [J].

Cipolat, Sara ;

Rudka, Tomasz ;

Hartmann, Dieter ;

Costa, Veronica ;

Serneels, Lutgarde ;

Craessaerts, Katleen ;

Metzger, Kristine ;

Frezza, Christian ;

Annaert, Wim ;

D'Adamio, Luciano ;

Derks, Carmen ;

Dejaegere, Tim ;

Pellegrini, Luca ;

D'Hooge, Rudi ;

Scorrano, Luca ;

De Strooper, Bart .

CELL, 2006, 126 (01) :163-175

[16] The Bcl-2 family: roles in cell survival and oncogenesis [J].

Cory, S ;

Huang, DCS ;

Adams, JM .

ONCOGENE, 2003, 22 (53) :8590-8607

[17] Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death [J].

Cribbs, J. Thomas ;

Strack, Stefan .

EMBO REPORTS, 2007, 8 (10) :939-944

[18] Mutation spectrum and splicing variants in the OPA1 gene [J].

Delettre, C ;

Griffoin, JM ;

Kaplan, J ;

Dollfus, H ;

Lorenz, B ;

Faivre, L ;

Lenaers, G ;

Belenguer, P ;

Hamel, CP .

HUMAN GENETICS, 2001, 109 (06) :584-591

[19] Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics [J].

Delivani, P ;

Adrain, C ;

Taylor, RC ;

Duriez, PJ ;

Martin, SJ .

MOLECULAR CELL, 2006, 21 (06) :761-773

[20] Mitochondria as the central control point of apoptosis [J].

Desagher, S ;

Martinou, JC .

TRENDS IN CELL BIOLOGY, 2000, 10 (09) :369-377

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