International Multicenter Psoriasis and Psoriatic Arthritis Reliability Trial for the Assessment of Skin, Joints, Nails, and Dactylitis

被引：77

作者：

Chandran, Vinod ^{[1
]}

Gottlieb, Alice ^{[2
]}

Cook, Richard J. ^{[3
]}

Duffin, Kristina Callis ^{[4
]}

Garg, Amit ^{[5
]}

Helliwell, Philip ^{[6
]}

Kavanaugh, Arthur ^{[7
]}

Krueger, Gerald G. ^{[4
]}

Langley, Richard G. ^{[8
]}

Lynde, Charles ^{[9
,10
]}

McHugh, Neil ^{[11
]}

Mease, Philip ^{[12
]}

Olivieri, Ignazio ^{[13
,14
]}

Rahman, Proton ^{[15
,16
]}

Rosen, Cheryl F. ^{[9
]}

Salvarani, Carlo ^{[17
]}

Thaci, Diamant ^{[18
]}

Toloza, Sergio M. A. ^{[1
]}

Wong, Maxine Yat Wing ^{[1
]}

Zhou, Qian M. ^{[3
]}

Gladman, Dafna D. ^{[1
,9
]}

机构：

[1] Toronto Western Hosp, Toronto, ON M5T 2S8, Canada

[2] Tufts Med Ctr, Boston, MA USA

[3] Univ Waterloo, Waterloo, ON N2L 3G1, Canada

[4] Univ Utah, Salt Lake City, UT USA

[5] Univ Massachusetts, Sch Med, Boston, MA 02125 USA

[6] Univ Leeds, Leeds, W Yorkshire, England

[7] Univ Calif San Diego, San Diego, CA 92103 USA

[8] Dalhousie Univ, Halifax, NS, Canada

[9] Univ Toronto, Toronto, ON, Canada

[10] Markham Stouffville Hosp, Toronto, ON, Canada

[11] Univ Bath, Bath BA2 7AY, Avon, England

[12] Univ Washington, Sch Med, Seattle, WA USA

[13] San Carlo Hosp, Potenza, Italy

[14] Madonna Grazie Hosp, Matera, Italy

[15] Mem Univ Newfoundland, St John, NF, Canada

[16] Clares Mercy Hosp, St John, NF, Canada

[17] Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

[18] Goethe Univ Frankfurt, Frankfurt, Germany

来源：

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH | 2009年 / 61卷 / 09期

关键词：

PHYSICIANS GLOBAL ASSESSMENT; INVOLVED SURFACE-AREA; SEVERITY INDEX; RHEUMATOID-ARTHRITIS; CLINICAL-TRIALS; OUTCOME MEASURES; ASSESSMENT TOOLS; CORE SET; THERAPY; DISEASE;

D O I：

10.1002/art.24562

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Clinical trials in psoriasis and psoriatic arthritis (PsA) involve assessment of the skin and joints. This study aimed to determine whether assessment of the skin and joints in patients with PsA by rheumatologists and dermatologists is reproducible. Methods. Ten rheurnatologists and 9 dermatologists from 7 countries met for a combined physical examination exercise to assess 20 PsA patients (11 men, mean age 51 years, mean PsA duration 11 years). Each physician assessed 10 patients according to a modified Latin square design that enabled the assessment of patient, assessor, and order effect. Tender joint count (TJC), swollen joint count (SJC), dactylitis, physician's global assessment (PGA) of PsA disease activity (PGA-PsA), psoriasis body surface area (BSA), Psoriasis Area and Severity Index (PASI), Lattice System Physician's Global Assessment of psoriasis (LS-PGA), National Psoriasis Foundation Psoriasis Score (NPF-PS), modified Nail Psoriasis Severity Index (mNAPSI), number of fingernails with nail changes (NN), and PGA of psoriasis activity (PGA-Ps) were assessed. Variance components analyses were carried out to estimate the intraclass correlation coefficient (ICC), adjusted for the order of measurements. Results. There is excellent agreement (ICC >= 0.80) on the mNAPSI, substantial agreement (0.6 >= ICC < 0.80) on the TJC, PASI, and NN, moderate agreement (0.4 >= ICC < 0.60) on the PGA-Ps, LS-PGA, NPF-PS, and BSA, and fair agreement (0.2 >= ICC<0.40) on the SJC, dactylitis, and PGA-PsA. The only measure that showed a significant difference between dermatologists and rheumatologists was dactylitis (P = 0.0005). Conclusion. There is substantial to excellent agreement on the TJC, PASI, NN, and mNAPSI among rheurnatologists and dermatologists.

引用

页码：1235 / 1242

页数：8

共 40 条

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