Neuronal Subtype Specification within a Lineage by Opposing Temporal Feed-Forward Loops

被引:133
作者
Baumgardt, Magnus [1 ]
Karlsson, Daniel [1 ]
Terriente, Javier [2 ]
Diaz-Benjumea, Fernando J. [2 ]
Thor, Stefan [1 ]
机构
[1] Linkoping Univ, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden
[2] Univ Autonoma Madrid Canto Blanco, CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
基金
瑞典研究理事会;
关键词
CENTRAL-NERVOUS-SYSTEM; TRANSCRIPTION FACTOR; DROSOPHILA CNS; NEUROBLAST COMPETENCE; NEURAL PROLIFERATION; IDENTITY FACTORS; GENE-EXPRESSION; NETWORK MOTIFS; CELL IDENTITY; HUNCHBACK;
D O I
10.1016/j.cell.2009.10.032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, many CNS lineages display broad temporal windows, and it is unclear how broad windows progress into subwindows that generate unique cell types. We have addressed this issue in an identifiable Drosophila CNS lineage and find that a broad castor temporal window is subdivided by two different feed-forward loops, both of which are triggered by castor itself. The first loop acts to specify a unique cell fate, whereas the second loop suppresses the first loop, thereby allowing for the generation of alternate cell fates. This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity.
引用
收藏
页码:969 / 982
页数:14
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