The biology of Toll-like receptors

被引:250
作者
Means, TK
Golenbock, DT
Fenton, MJ
机构
[1] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA
[2] Boston Univ, Med Ctr, Infect Dis Sect, Boston, MA 02118 USA
关键词
Toll; LPS; lipid A; LAM; IL-1; intracellular signaling;
D O I
10.1016/S1359-6101(00)00006-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In 1997, a human homologue of the Drosphila Toll protein was described, a protein later to be designated Toll-like receptor 4 (TLR4). Since that time, additional human and murine TLR proteins have been identified. Mammalian TLR proteins appeal to represent a conserved family of innate immune recognition receptors. These receptors are coupled to a signaling pathway that is conserved in mammals, insects, and plants, resulting in the activation of genes that mediate innate immune defenses. Numerous studies have now identified a wide variety of chemically-diverse bacterial products that serve as putative ligands for TLR proteins. More recent studies have identified the first endogenous protein ligands for TLR proteins. TLR signaling represents a key Feature of innate immune response to pathogen invasion. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:219 / 232
页数:14
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