Genetic and epigenetic changes in nasopharyngeal carcinoma

被引：220

作者：

Lo, KW ^{[1
]}

Huang, DP

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Inst Mol Oncol, Hong Kong, Hong Kong, Peoples R China

来源：

SEMINARS IN CANCER BIOLOGY | 2002年 / 12卷 / 06期

关键词：

Epstein-Barr virus; nasopharyngeal carcinoma; methylation; pathogenesis; tumour suppressor gene;

D O I：

10.1016/S1044579X02000883

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable racial and geographic distribution. The development of this EBV-associated cancer likely involves cumulative genetic and epigenetic changes in a background of predisposed genetic and environmental factors. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumour suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of EBV latent infection in the development of this cancer. Based on the existing findings, a pathogenetic model for NPC is proposed.

引用

页码：451 / 462

页数：12

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