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Development, dimensions, reliability and validity of the novel Manchester COPD fatigue scale
被引:38
作者:
Al-shair, K.
[1
]
Kolsum, U.
Berry, P.
[2
]
Smith, J.
Caress, A.
[3
]
Singh, D.
Vestbo, J.
机构:
[1] Univ Manchester, S Manchester Univ Hosp NHS Fdn Trust, Educ & Res Ctr, Resp Res Grp, Manchester M23 9LT, Lancs, England
[2] GlaxoSmithKline, Global Hlth Outcomes, London, England
[3] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M23 9LT, Lancs, England
来源:
基金:
英国医学研究理事会;
关键词:
OBSTRUCTIVE PULMONARY-DISEASE;
QUALITY-OF-LIFE;
HEALTH-STATUS;
QUESTIONNAIRE;
DEPRESSION;
VALIDATION;
SYMPTOMS;
DYSPNEA;
D O I:
10.1136/thx.2009.118109
中图分类号:
R56 [呼吸系及胸部疾病];
学科分类号:
摘要:
Introduction: Fatigue is a prominent symptom in chronic obstructive pulmonary disease (COPD) and it has distinctive features; however, there is a need for a robust scale to measure fatigue in COPD. Methods: At baseline, 122 patients with COPD (forced expiratory volume in 1 s (FEV1) 52%, women 38%, mean age 66 years) completed a pilot fatigue scale covering a pool of 57 items and underwent a range of tests, including indicators of mood and a short general fatigue questionnaire. All patients responded to the 57-item scale and it was readministered to a subset of 30 patients. The pilot scale was first subjected to constructive validated shortening steps and then to a principal components analysis. Results: The Manchester COPD fatigue scale (MCFS) consists of 27 items, loading into three dimensions: physical, cognitive and psychosocial fatigue. Internal consistency (Cronbach's alpha=0.97) and test-retest repeatability (r=0.97, p<0.001) were tested. It had significant convergent validity, correlating with the FACIT (Functional Assessment of Chronic Illness Therapy) fatigue scale and the fatigue in Borg scale at baseline and after a 6 minute walk distance (6MWD) test (r=-0.81, 0.53 and 0.63, respectively, p<0.001). Its scores were associated with BODE, SGRQ (St George's Respiratory Questionnaire) and MRC (Medical Research Council) dyspnoea scores (r=0.46, 0.8 and 0.51, respectively, p<0.001). The scale demonstrated meaningful discriminating ability; patients who walked,350 m in a 6MWD test as well as depressed patients (>= 16 scores in the Center for Epidemiologic Study on Depression (CES-D) scale) had nearly twice as high fatigue scores as those who walked >= 350 m or were not depressed (p<0.001). Conclusion: The MCFS provides a simple, reliable and valid measurement of total and dimensional fatigue in moderate stable COPD.
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页码:950 / 955
页数:6
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