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Molecular basis for anti-amyloid therapy in the prevention and treatment of Alzheimer's disease

被引：26
作者：
Gandy, S [1 ]
机构：
[1] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA
来源：
NEUROBIOLOGY OF AGING | 2002年 / 23卷 / 06期
关键词：
amyloid; Alzheimer's disease (AD); amyloid precursor protein (APP); secretase; estrogen; protein phosphorylation;
D O I：
10.1016/S0197-4580(02)00125-2
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
[No abstract available]
引用
收藏
页码：1009 / 1016
页数：8
相关论文
共 69 条
  • [61] APOLIPOPROTEIN-E - HIGH-AVIDITY BINDING TO BETA-AMYLOID AND INCREASED FREQUENCY OF TYPE-4 ALLELE IN LATE-ONSET FAMILIAL ALZHEIMER-DISEASE
    STRITTMATTER, WJ
    SAUNDERS, AM
    SCHMECHEL, D
    PERICAKVANCE, M
    ENGHILD, J
    SALVESEN, GS
    ROSES, AD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) : 1977 - 1981
  • [62] Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
    Tang, MX
    Jacobs, D
    Stern, Y
    Marder, K
    Schofield, P
    Gurland, B
    Andrews, H
    Mayeux, R
    [J]. LANCET, 1996, 348 (9025) : 429 - 432
  • [63] A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
    Weggen, S
    Eriksen, JL
    Das, P
    Sagi, SA
    Wang, R
    Pietrzik, CU
    Findlay, KA
    Smith, TE
    Murphy, MP
    Butler, T
    Kang, DE
    Marquez-Sterling, N
    Golde, TE
    Koo, EH
    [J]. NATURE, 2001, 414 (6860) : 212 - 216
  • [64] APOLIPOPROTEIN-E - A PATHOLOGICAL CHAPERONE PROTEIN IN PATIENTS WITH CEREBRAL AND SYSTEMIC AMYLOID
    WISNIEWSKI, T
    FRANGIONE, B
    [J]. NEUROSCIENCE LETTERS, 1992, 135 (02) : 235 - 238
  • [65] XU H, 1995, J BIOL CHEM, V270, P21243
  • [66] Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
    Xu, HX
    Gouras, GK
    Greenfield, JP
    Vincent, B
    Naslund, J
    Mazzarelli, L
    Fried, G
    Jovanovic, JN
    Seeger, M
    Relkin, NR
    Liao, F
    Checler, F
    Buxbaum, JD
    Chait, BT
    Thinakaran, G
    Sisodia, SS
    Wang, R
    Greengard, P
    Gandy, S
    [J]. NATURE MEDICINE, 1998, 4 (04) : 447 - 451
  • [67] Estrogen therapy in postmenopausal women - Effects on cognitive function and dementia
    Yaffe, K
    Sawaya, G
    Lieberburg, I
    Grady, D
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (09): : 688 - 695
  • [68] Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner
    Yang, DS
    Small, DH
    Seydel, U
    Smith, JD
    Hallmayer, J
    Gandy, SE
    Martins, RN
    [J]. NEUROSCIENCE, 1999, 90 (04) : 1217 - 1226
  • [69] Modulation of Aβ peptides by estrogen in mouse models
    Zheng, H
    Xu, H
    Uljon, SN
    Gross, R
    Hardy, K
    Gaynor, J
    Lafrancois, J
    Simpkins, J
    Refolo, LM
    Petanceska, S
    Wang, R
    Duff, K
    [J]. JOURNAL OF NEUROCHEMISTRY, 2002, 80 (01) : 191 - 196
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