The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses

被引：306

作者：

Bergelson, JM

Krithivas, A

Celi, L

Droguett, G

Horwitz, MS

Wickham, T

Crowell, RL

Finberg, RW

机构：

[1] DANA FARBER CANC INST,DIV INFECT DIS,BOSTON,MA 02115

[2] ALBERT EINSTEIN COLL MED,DEPT MICROBIOL IMMUNOL,BRONX,NY 10461

[3] ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461

[4] GENVEC INC,ROCKVILLE,MD 20852

[5] MED COLL PENN & HAHNEMANN UNIV,DEPT MICROBIOL & IMMUNOL,PHILADELPHIA,PA 19102

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 01期

关键词：

D O I：

10.1128/JVI.72.1.415-419.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.

引用

页码：415 / 419

页数：5

共 34 条

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