'Transmitted' remote double diastereoselection effects on the asymmetric reduction of β-boronate oxime ethers

被引：19

作者：

Sailes, HE

Watts, JP

Whiting, A

机构：

[1] UMIST, Dept Chem, Manchester M60 1QD, Lancs, England

[2] Knoll Pharmaceut, Res & Dev, Nottingham NG1 1GF, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)00179-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Remote asymmetric induction in the reduction of a homochiral beta-boronate oxime ether to the corresponding amine failed to provide asymmetric induction with achiral reducing agents, but use of a chiral reducing agent produced extreme double diastereoselection effects which show that remote asymmetry can be 'transmitted' by suitable choice of a 'partner' molecule. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

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页码：2457 / 2461

页数：5

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