The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats

被引：69

作者：

Yang, J

Klaidman, LK

Nalbandian, A

Oliver, J

Chang, ML

Chan, PH

Adams, JD

机构：

[1] Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90089 USA

[2] Stanford Univ, Sch Med, Dept Neurosurg, Neurosurg Labs, Palo Alto, CA 94304 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 333卷 / 02期

关键词：

nicotinamide; ketamine; middle cerebral artery occulusion model; adenosine triphosphate; nicotinamide adenine; DNA fragmentation;

D O I：

10.1016/S0304-3940(02)01005-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the effects of nicotinamide on adenosine triphosphate (ATP) and nicotinamide adenine (NAD) levels and poly(adenosine diphosphate-ribose) (poly(ADP-ribose)) polymerase activity following ischemia and reperfusion in ketamine pretreated rats. Nicotinamide was administered at the end of the ischemic period. Nicotinamide protected against the depletion of ATP and NAD at 6 and 24 h of reperfusion. Nicotinamide is known to inhibit poly(ADP-ribose) polymerase at early time points, but was found to increase poly(ADP-ribose) polymerase activity at 24 h of reperfusion. It appears that nicotinamide can help maintain cellular energetics during reperfusion, thereby protecting cells from necrotic and apoptotic mechanisms. (C) 2002 Published by Elsevier Science Ireland Ltd.

引用

页码：91 / 94

页数：4

共 17 条

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[3]

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