A solid-phase route to 18F-labeled tracers, exemplified by the synthesis of [18F]2-fluoro-2-deoxy-D-glucose

被引：32

作者：

Brown, Lynda J.

Bouvet, Denis R.

Champion, Sue

Gibson, Alex M.

Hu, Yulai

Jackson, Alex

Khan, Imtiaz

Ma, Nianchun

Millot, Nicholas

Wadsworth, Harry

Brown, Richard C. D. ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[2] GE Healthcare, Grove Ctr, Amersham HP7 9LL, Bucks, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 06期

关键词：

fluorine; positron emission tomography; radiopharmaceuticals; solid-phase synthesis; synthetic methods;

D O I：

10.1002/anie.200603394

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Scintillating synthesis: 18F- Containing radiopharmaceuticals can be prepared by using [18F] fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM = ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [18F]fluoro-2-deoxy-D- glucose in good radiochemical yield and with high chemical purity. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：941 / 944

页数：4

共 37 条

[1] What does positron emission tomography offer oncology? [J].