Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

被引：1063

作者：

Chen, Mo ^{[1
]}

Manley, James L. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PRE-MESSENGER-RNA; TRACT-BINDING-PROTEIN; SPINAL MUSCULAR-ATROPHY; NUCLEAR RIBONUCLEOPROTEIN-H; HNRNP A1; SR PROTEINS; 5'-SPLICE-SITE SELECTION; GENE-EXPRESSION; SITE SELECTION; PHOSPHORYLATION;

D O I：

10.1038/nrm2777

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression of most genes. Alternative splicing markedly affects human development, and its misregulation underlies many human diseases. Although the mechanisms of alternative splicing have been studied extensively, until the past few years we had not begun to realize fully the diversity and complexity of alternative splicing regulation by an intricate protein-RNA network. Great progress has been made by studying individual transcripts and through genome-wide approaches, which together provide a better picture of the mechanistic regulation of alternative pre-mRNA splicing.

引用

页码：741 / 754

页数：14

共 164 条

[1]

Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes [J].