Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans

被引:28
作者
El-Gharbawy, AH
Kotchen, JM
Grim, CE
Kaldunski, M
Hoffmann, RG
Pausova, Z
Hamet, P
Kotchen, TA
机构
[1] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA
[3] Med Coll Wisconsin, Dept Biostat, Milwaukee, WI 53226 USA
[4] Med Coll Wisconsin, Dept Epidemiol, Milwaukee, WI 53226 USA
[5] Univ Montreal, Ctr Hosp, Montreal, PQ, Canada
关键词
African American; leptin; obesity-related hypertension;
D O I
10.1016/S0895-7061(02)03089-3
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P < .03) in hypertensive women than in normotensive women, although body mass index did not differ (30.5 +/- 0.5 v 30.2 +/- 0.8 kg/m(2)). After adjusting for obesity and insulin resistance, there were no significant relationships between leptin and BP; however, leptin independently predicted 28% of the variability of heart rate in hypertensive men (P <.01) and 18% of the variability of lithium clearance in hypertensive women (P <.01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption. Am J Hypertens 2002;15:989-993 (C) 2002 American Journal of Hypertension, Ltd.
引用
收藏
页码:989 / 993
页数:5
相关论文
共 19 条
  • [11] The role of leptin in human obesity and disease: A review of current evidence
    Mantzoros, CS
    [J]. ANNALS OF INTERNAL MEDICINE, 1999, 130 (08) : 671 - 680
  • [12] Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
    Mark, AL
    Correia, MLG
    Rahmouni, K
    Haynes, WG
    [J]. JOURNAL OF HYPERTENSION, 2002, 20 (07) : 1245 - 1250
  • [13] Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects
    Narkiewicz, K
    Kato, M
    Phillips, BG
    Pesek, CA
    Choe, I
    Winnicki, M
    Palatini, P
    Sivitz, WI
    Somers, VK
    [J]. JOURNAL OF HYPERTENSION, 2001, 19 (06) : 1089 - 1094
  • [14] Chronic leptin infusion increases arterial pressure
    Shek, EW
    Brands, MW
    Hall, JE
    [J]. HYPERTENSION, 1998, 31 (01) : 409 - 414
  • [15] High plasma leptin concentrations in hypertensive men but not in hypertensive women
    Sheu, WHH
    Lee, WJ
    Chen, YT
    [J]. JOURNAL OF HYPERTENSION, 1999, 17 (09) : 1289 - 1295
  • [16] Leptin and blood pressure - is there a link?
    Stenvinkel, P
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 (08) : 1115 - 1117
  • [17] Gender difference in the relationships among hyperleptinemia, hyperinsulinemia, and hypertension
    Takizawa, H
    Ura, N
    Saitoh, S
    Wang, L
    Higashiura, K
    Takagi, S
    Takada, M
    Togashi, N
    Nakano, M
    Hayashi, Y
    Shimamoto, K
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION, 2001, 23 (04) : 357 - 368
  • [18] Renal effects of leptin in normotensive, hypertensive, and obese rats
    Villarreal, D
    Reams, G
    Freeman, RH
    Taraben, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 275 (06) : R2056 - R2060
  • [19] Hypertensive cardiovascular disease in African Americans
    Wali R.K.
    Weir M.R.
    [J]. Current Hypertension Reports, 1999, 1 (6) : 521 - 528