CD4-CD8 Lineage Differentiation: Thpok-ing into the Nucleus

被引：57

作者：

Wang, Lie ^{[1
]}

Bosselut, Remy ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 05期

基金：

美国国家卫生研究院;

关键词：

T-CELL DEVELOPMENT; TRANSCRIPTION FACTOR GATA-3; SINGLE-POSITIVE LINEAGE; HELPER TYPE-1 CELLS; LYMPHOCYTE DEVELOPMENT; TRANSGENIC MICE; RUNX PROTEINS; THYMOCYTE DIFFERENTIATION; ANTIGEN RECEPTOR; GENE-EXPRESSION;

D O I：

10.4049/jimmunol.0901041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mature alpha beta T cell population is divided into two main lineages that are defined by the mutually exclusive expression of CD4 and CD8 surface molecules (coreceptors) and that differ in their MHC restriction and function. CD4 T cells are typically MHC-II restricted and helper (or regulatory), whereas CD8 T cells are typically cytotoxic. Several transcription factors are known to control the emergence of CD4 and CD8 lineages, including the zinc finger proteins Thpok and Gata3, which are required for CD4 lineage differentiation, and the Runx factors Runx1 and Runx3, which contribute to CD8 lineage differentiation. This review summarizes recent advances on the function of these transcription factors in lineage differentiation. We also discuss how the "circuitry" connecting these factors could operate to match the expression of the lineage-committing factors Thpok and Runx3, and therefore lineage differentiation, to MHC specificity. The Journal of Immunology, 2009, 183: 2903-2910.

引用

页码：2903 / 2910

页数：8

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