Sensing the environment: lessons from fungi

被引:276
作者
Bahn, Yong-Sun
Xue, Chaoyang
Idnurm, Alexander
Rutherford, Julian C.
Heitman, Joseph
Cardenas, Maria E.
机构
[1] Duke Univ, Med Ctr, Dept Mol Genet, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA
[3] Soongsil Univ, Dept Bioinformat & Life Sci, Seoul 156743, South Korea
[4] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA
关键词
D O I
10.1038/nrmicro1578
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
All living organisms use numerous signal-transduction systems to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we review recent progress in our understanding of how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental cues.
引用
收藏
页码:57 / 69
页数:13
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