Melanisation of Cryptococcus neoformans in human brain tissue

被引：98

作者：

Nosanchuk, JD

Rosas, AL

Lee, SC

Casadevall, A ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

来源：

LANCET | 2000年 / 355卷 / 9220期

关键词：

D O I：

10.1016/S0140-6736(00)02356-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Melanin-specific reagents revealed melanin in cryptococcal cell walls from human brain tissue, and fungal-cell melanin "ghosts" were recovered from infected tissue. The results indicate that Cryptococcus neoformans melanises during human infection.

引用

页码：2049 / 2050

页数：2

共 5 条

[1] Antioxidant systems in the pathogenic fungi of man and their role in virulence [J].

Hamilton, AJ ;

Holdom, MD .

MEDICAL MYCOLOGY, 1999, 37 (06) :375-389

[2] Evidence that Cryptococcus neoformans is melanized in pigeon excreta:: Implications for pathogenesis [J].

Nosanchuk, JD ;

Rudolph, J ;

Rosas, AL ;

Casadevall, A .

INFECTION AND IMMUNITY, 1999, 67 (10) :5477-5479

[3]

Nosanchuk JD, 1999, MOL CELL BIOL, V19, P745

[4]

ROSAS AL, IN PRESS INFECT IMMU

[5] Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine [J].

Wang, YL ;

Casadevall, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (03) :541-545

← 1 →