Heat Shock Protein 90: Inhibitors in Clinical Trials

被引：226

作者：

Biamonte, Marco A. ^{[1
]}

Van de Water, Ryan ^{[1
]}

Arndt, Joseph W. ^{[2
]}

Scannevin, Robert H. ^{[2
]}

Perret, Daniel ^{[1
]}

Lee, Wen-Cherng ^{[2
]}

机构：

[1] Biogen Idec Inc, San Diego, CA 92122 USA

[2] Biogen Idec Inc, Cambridge, MA 02142 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 01期

关键词：

FLUORESCENCE POLARIZATION ASSAY; HSP90 MOLECULAR CHAPERONE; POTENT ANTITUMOR-ACTIVITY; ESCHERICHIA-COLI HSP90; CRYSTAL-STRUCTURE; BREAST-CANCER; IN-VITRO; HEAT-SHOCK-PROTEIN-90; INHIBITORS; GELDANAMYCIN DERIVATIVES; MULTIPLE-MYELOMA;

D O I：

10.1021/jm9004708

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3 / 17

页数：15

共 102 条

[1]

AGATSUMA T, 1996, Patent No. 9633989

[2] Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex [J].

Ali, MMU ;

Roe, SM ;

Vaughan, CK ;

Meyer, P ;

Panaretou, B ;

Piper, PW ;

Prodromou, C ;

Pearl, LH .

NATURE, 2006, 440 (7087) :1013-1017

[3]

*ASCO, 2007, ASCO ANN M

[4]

*ASH, 2006, 48 ASH M ORL FL DEC

[5]

Ballinger CA, 1999, MOL CELL BIOL, V19, P4535

[6] Phase I pharmacokinetic and pharmacodynarnic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies [J].

Banerji, U ;

O'Donnell, A ;

Scurr, M ;

Pacey, S ;

Stapleton, S ;

Asad, Y ;

Simmons, L ;

Maloney, A ;

Raynaud, F ;

Campbell, M ;

Walton, M ;

Lakhani, S ;

Kaye, S ;

Workman, P ;

Judson, I .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (18) :4152-4161

[7] Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models [J].

Banerji, U ;

Walton, M ;

Raynaud, F ;

Grimshaw, R ;

Kelland, L ;

Valenti, M ;

Judson, I ;

Workman, P .

CLINICAL CANCER RESEARCH, 2005, 11 (19) :7023-7032

[8] Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 [J].

Barta, Thomas E. ;

Veal, James M. ;

Rice, John W. ;

Partridge, Jeffrey M. ;

Fadden, R. Patrick ;

Ma, Wei ;

Jenks, Matthew ;

Geng, Lifeng ;

Hanson, Gunnar J. ;

Huang, Kenneth H. ;

Barabasz, Amy F. ;

Foley, Briana E. ;

Otto, James ;

Hall, Steven E. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (12) :3517-3521

[9] Orally active purine-based inhibitors of the heat shock protein 90 [J].

Biamonte, MA ;

Shi, JD ;

Hong, K ;

Hurst, DC ;

Zhang, L ;

Fan, JH ;

Busch, DJ ;

Karjian, PL ;

Maldonado, AA ;

Sensintaffar, JL ;

Yang, YC ;

Kamal, A ;

Lough, RE ;

Lundgren, K ;

Burrows, FJ ;

Timony, GA ;

Boehm, MF ;

Kasibhatla, SR .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (02) :817-828

[10] 4,5-diarylisoxazole HSP90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer [J].

Brough, Paul A. ;

Aherne, Wynne ;

Barril, Xavier ;

Borgognoni, Jenifer ;

Boxall, Kathy ;

Cansfield, Julie E. ;

Cheung, Kwai-Miny J. ;

Collins, Ian ;

Davies, Nicholas G. M. ;

Drysdale, Martin J. ;

Dymock, Brian ;

Eccles, Suzanne A. ;

Finch, Harry ;

Fink, Alexandra ;

Hayes, Angela ;

Howes, Robert ;

Hubbard, Roderick E. ;

James, Karen ;

Jordan, Allan M. ;

Lockie, Andrea ;

Martins, Vanessa ;

Massey, Andrew ;

Matthews, Thomas P. ;

McDonald, Edward ;

Northfield, Christopher J. ;

Pearl, Laurence H. ;

Prodromou, Chrisostomos ;

Ray, Stuart ;

Raynaud, Florence I. ;

Roughley, Stephen D. ;

Sharp, Swee Y. ;

Surgenor, Allan ;

Walmsley, D. Lee ;

Webb, Paul ;

Wood, Mike ;

Workman, Paul ;

Wrightt, Lisa .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (02) :196-218

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